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Crystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation
Prethrombin-2 is the immediate zymogen precursor of the clotting enzyme thrombin, which is generated upon cleavage at R15 and separation of the A chain and catalytic B chain. The X-ray structure of prethrombin-2 solved in the free form at 1.9 Å resolution shows the 215–217 segment collapsed into the...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549457/ https://ncbi.nlm.nih.gov/pubmed/22049947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2015019 |
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