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Interplay between conformational selection and zymogen activation
Trypsin-like proteases are synthesized as zymogens and activated through a mechanism that folds the active site for efficient binding and catalysis. Ligand binding to the active site is therefore a valuable source of information on the changes that accompany zymogen activation. Using the physiologic...
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| Publicado en: | Sci Rep |
|---|---|
| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5840343/ https://ncbi.nlm.nih.gov/pubmed/29511224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21728-9 |
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