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Crystal structure of prethrombin-1

Prothrombin is the zymogen precursor of the clotting enzyme thrombin, which is generated by two sequential cleavages at R271 and R320 by the prothrombinase complex. The structure of prothrombin is currently unknown. Prethrombin-1 differs from prothrombin for the absence of 155 residues in the N-term...

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Bibliographic Details
Main Authors: Chen, Zhiwei, Pelc, Leslie A., Di Cera, Enrico
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984181/
https://ncbi.nlm.nih.gov/pubmed/20974933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010262107
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