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The linker connecting the two kringles plays a key role in prothrombin activation
The zymogen prothrombin is proteolytically converted by factor Xa to the active protease thrombin in a reaction that is accelerated >3,000-fold by cofactor Va. This physiologically important effect is paradigmatic of analogous cofactor-dependent reactions in the coagulation and complement cascade...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040597/ https://ncbi.nlm.nih.gov/pubmed/24821807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403779111 |
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