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How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin
A flexible linker (Lnk2) composed of 26 amino acids connects kringle-1 to kringle-2 in the coagulation factor prothrombin. Recent studies point to Lnk2 as a key determinant of the structure and function of this zymogen. Using a combination of mutagenesis, structural biology, and single molecule spec...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4813588/ https://ncbi.nlm.nih.gov/pubmed/26763231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.700401 |
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