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Crystal Structure of Prothrombin Reveals Conformational Flexibility and Mechanism of Activation
The zymogen prothrombin is composed of fragment 1 containing a Gla domain and kringle-1, fragment 2 containing kringle-2, and a protease domain containing A and B chains. The prothrombinase complex assembled on the surface of platelets converts prothrombin to thrombin by cleaving at Arg-271 and Arg-...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3829358/ https://ncbi.nlm.nih.gov/pubmed/23775088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.466946 |
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