Loading...

Rational Design of Protein C Activators

In addition to its procoagulant and proinflammatory functions mediated by cleavage of fibrinogen and PAR1, the trypsin-like protease thrombin activates the anticoagulant protein C in a reaction that requires the cofactor thrombomodulin and the endothelial protein C receptor. Once in the circulation,...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Barranco-Medina, Sergio, Murphy, Mary, Pelc, Leslie, Chen, Zhiwei, Di Cera, Enrico, Pozzi, Nicola
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353707/
https://ncbi.nlm.nih.gov/pubmed/28294177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44596
Tags: Add Tag
No Tags, Be the first to tag this record!