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Rational Design of Protein C Activators

In addition to its procoagulant and proinflammatory functions mediated by cleavage of fibrinogen and PAR1, the trypsin-like protease thrombin activates the anticoagulant protein C in a reaction that requires the cofactor thrombomodulin and the endothelial protein C receptor. Once in the circulation,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Barranco-Medina, Sergio, Murphy, Mary, Pelc, Leslie, Chen, Zhiwei, Di Cera, Enrico, Pozzi, Nicola
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353707/
https://ncbi.nlm.nih.gov/pubmed/28294177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44596
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