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Rational Design of Protein C Activators
In addition to its procoagulant and proinflammatory functions mediated by cleavage of fibrinogen and PAR1, the trypsin-like protease thrombin activates the anticoagulant protein C in a reaction that requires the cofactor thrombomodulin and the endothelial protein C receptor. Once in the circulation,...
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| Published in: | Sci Rep |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5353707/ https://ncbi.nlm.nih.gov/pubmed/28294177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44596 |
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