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Exposure of R169 controls protein C activation and autoactivation
Protein C is activated by thrombin with a value of k(cat)/K(m) = 0.11mM(−1)s(−1) that increases 1700-fold in the presence of the cofactor thrombomodulin. The molecular origin of this effect triggering an important feedback loop in the coagulation cascade remains elusive. Acidic residues in the activ...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401217/ https://ncbi.nlm.nih.gov/pubmed/22535660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415323 |
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