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Exposure of R169 controls protein C activation and autoactivation
Protein C is activated by thrombin with a value of k(cat)/K(m) = 0.11mM(−1)s(−1) that increases 1700-fold in the presence of the cofactor thrombomodulin. The molecular origin of this effect triggering an important feedback loop in the coagulation cascade remains elusive. Acidic residues in the activ...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society of Hematology
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401217/ https://ncbi.nlm.nih.gov/pubmed/22535660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415323 |
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