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Exposure of R169 controls protein C activation and autoactivation

Protein C is activated by thrombin with a value of k(cat)/K(m) = 0.11mM(−1)s(−1) that increases 1700-fold in the presence of the cofactor thrombomodulin. The molecular origin of this effect triggering an important feedback loop in the coagulation cascade remains elusive. Acidic residues in the activ...

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Autori principali: Pozzi, Nicola, Barranco-Medina, Sergio, Chen, Zhiwei, Di Cera, Enrico
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401217/
https://ncbi.nlm.nih.gov/pubmed/22535660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415323
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