Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-Synucleinopathy In Vivo

In Parkinson's disease (PD) and other α-synucleinopathies, prefibrillar α-synuclein (αS) oligomer is implicated in the pathogenesis. However, toxic αS oligomers observed using in vitro systems are not generally seen to be associated with α-synucleinopathy in vivo. Thus, the pathologic significa...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Colla, Emanuela, Jensen, Poul H., Pletnikova, Olga, Troncoso, Juan C., Glabe, Charles, Lee, Michael K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2012
Témata:
Brief Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548448/
https://ncbi.nlm.nih.gov/pubmed/22399752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5368-11.2012
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky