Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-Synucleinopathy In Vivo

In Parkinson's disease (PD) and other α-synucleinopathies, prefibrillar α-synuclein (αS) oligomer is implicated in the pathogenesis. However, toxic αS oligomers observed using in vitro systems are not generally seen to be associated with α-synucleinopathy in vivo. Thus, the pathologic significa...

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Autors principals: Colla, Emanuela, Jensen, Poul H., Pletnikova, Olga, Troncoso, Juan C., Glabe, Charles, Lee, Michael K.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2012
Matèries:
Brief Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548448/
https://ncbi.nlm.nih.gov/pubmed/22399752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5368-11.2012
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