Endoplasmic Reticulum Stress Is Important for the Manifestations of α-Synucleinopathy In Vivo

Accumulation of misfolded α-synuclein (αS) is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other α-synucleinopathies. However, how αS causes neurodegeneration is unresolved. Because cellular accumulation of misfolded proteins can lead to endoplasmic reticulum stre...

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Autores principales: Colla, Emanuela, Coune, Philippe, Liu, Ying, Pletnikova, Olga, Troncoso, Juan C, Iwatsubo, Takeshi, Schneider, Bernard L., Lee, Michael K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2012
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461828/
https://ncbi.nlm.nih.gov/pubmed/22399753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5367-11.2012
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