α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment

BACKGROUND: Studies link c-Abl activation with the accumulation of pathogenic α-synuclein (αS) and neurodegeneration in Parkinson’s disease (PD). Currently, c-Abl, a tyrosine kinase activated by cellular stress, is thought to promote αS pathology by either directly phosphorylating αS or by causing a...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Karim, Md. Razaul, Liao, Elly E., Kim, Jaekwang, Meints, Joyce, Martinez, Hector Martell, Pletnikova, Olga, Troncoso, Juan C., Lee, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164361/
https://ncbi.nlm.nih.gov/pubmed/32299471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00364-w
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