Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Homeostasis of self-renewing small intestinal crypts results from neutral competition between Lgr5 stem cells, small cycling cells located at crypt bottoms(1, 2). Lgr5 stem cells are interspersed between terminally differentiated Paneth cells, that are known to produce bactericidal products such as...

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Main Authors: Sato, Toshiro, van Es, Johan H., Snippert, Hugo J., Stange, Daniel E., Vries, Robert G., van den Born, Maaike, Barker, Nick, Shroyer, Noah F., van de Wetering, Marc, Clevers, Hans
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547360/
https://ncbi.nlm.nih.gov/pubmed/21113151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09637
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