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The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair
Telomeres protect the natural ends of chromosomes from being repaired as deleterious DNA breaks. In fission yeast, absence of Taz1 (homologue of human TRF1 and TRF2) renders telomeres vulnerable to DNA repair. During the G1 phase, when non-homologous end joining (NHEJ) is upregulated, taz1Δ cells un...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
European Molecular Biology Organization
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545291/ https://ncbi.nlm.nih.gov/pubmed/23188080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.313 |
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