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Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells

Telomeres protect eukaryotic chromosomes from illegitimate end-to-end fusions. When this function fails, dicentric chromosomes are formed, triggering breakage-fusion-bridge cycles and genome instability. How efficient is this protection mechanism in normal cells is not fully understood. We created a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Almeida, Hugo, Godinho Ferreira, Miguel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597658/
https://ncbi.nlm.nih.gov/pubmed/23335786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1459
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