The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair

Telomeres protect the natural ends of chromosomes from being repaired as deleterious DNA breaks. In fission yeast, absence of Taz1 (homologue of human TRF1 and TRF2) renders telomeres vulnerable to DNA repair. During the G1 phase, when non-homologous end joining (NHEJ) is upregulated, taz1Δ cells un...

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Hauptverfasser: Reis, Clara Correia, Batista, Sílvia, Ferreira, Miguel Godinho
Format: Artigo
Sprache:Inglês
Veröffentlicht: European Molecular Biology Organization 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545291/
https://ncbi.nlm.nih.gov/pubmed/23188080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.313
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