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The MRN complex in Double-Strand Break Repair and Telomere Maintenance

Genomes are subject to constant threat by damaging agents that generate DNA double-strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end-joining, and this is achieved through protein-DNA complexes known as telomeres. The Mre11-Rad50-Nbs1 (MRN)...

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Autors principals: Lamarche, Brandon J, Orazio, Nicole I, Weitzman, Matthew D
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946096/
https://ncbi.nlm.nih.gov/pubmed/20655309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.07.029
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