The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair

Telomeres protect the natural ends of chromosomes from being repaired as deleterious DNA breaks. In fission yeast, absence of Taz1 (homologue of human TRF1 and TRF2) renders telomeres vulnerable to DNA repair. During the G1 phase, when non-homologous end joining (NHEJ) is upregulated, taz1Δ cells un...

Full description

Saved in:
Bibliographic Details
Main Authors: Reis, Clara Correia, Batista, Sílvia, Ferreira, Miguel Godinho
Format: Artigo
Language:Inglês
Published: European Molecular Biology Organization 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545291/
https://ncbi.nlm.nih.gov/pubmed/23188080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.313
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items