A carregar...
Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G(1) and Resection-Mediated Inhibition of NHEJ in G(2)
Here, we address the role of the MRN (Mre11/Rad50/Nbs1) complex in the response to telomeres rendered dysfunctional by deletion of the shelterin component TRF2. Using conditional NBS1/TRF2 double-knockout MEFs, we show that MRN is required for ATM signaling in response to telomere dysfunction. This...
Na minha lista:
| Main Authors: | , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756883/ https://ncbi.nlm.nih.gov/pubmed/19667071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00476-09 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|