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Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicity in Vitro and in Vivo

Because oxidative stress and mitochondrial dysfunction are well known contributors to Parkinson disease (PD), we set out to investigate the role mitochondrial JNK plays in the etiology of 6-hydroxydopamine-induced (6-OHDA) oxidative stress, mitochondrial dysfunction, and neurotoxicity in SHSY5Y cell...

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Библиографические подробности
Главные авторы: Chambers, Jeremy W., Howard, Shannon, LoGrasso, Philip V.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542993/
https://ncbi.nlm.nih.gov/pubmed/23184940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421354
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