Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicity in Vitro and in Vivo

Because oxidative stress and mitochondrial dysfunction are well known contributors to Parkinson disease (PD), we set out to investigate the role mitochondrial JNK plays in the etiology of 6-hydroxydopamine-induced (6-OHDA) oxidative stress, mitochondrial dysfunction, and neurotoxicity in SHSY5Y cell...

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Detalles Bibliográficos
Autores principales: Chambers, Jeremy W., Howard, Shannon, LoGrasso, Philip V.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542993/
https://ncbi.nlm.nih.gov/pubmed/23184940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421354
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