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Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin’s Anorectic Signaling Actions

The role for c-Jun N-terminal Kinase (JNK) in the control of feeding and energy balance is not well understood. Here, by use of novel and highly selective JNK inhibitors, we investigated the actions of JNK in the control of feeding and body weight homeostasis. In lean mice, intraperitoneal (i.p.) or...

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Pubblicato in:Sci Rep
Autori principali: Gao, Su, Howard, Shannon, LoGrasso, Philip V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292945/
https://ncbi.nlm.nih.gov/pubmed/28165482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41795
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