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It takes two to tango: PROPPINs use two phosphoinositide-binding sites
PROPPINs are a family of PtdIns3P and PtdIns(3,5)P(2)-binding proteins. The crystal structure now unravels the presence of two distinct phosphoinositide-binding sites at the circumference of the seven bladed β-propeller. Mutagenesis analysis of the binding sites shows that both are required for norm...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3542210/ https://ncbi.nlm.nih.gov/pubmed/23069643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.22400 |
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