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Structure based biophysical characterization of the PROPPIN Atg18 shows Atg18 oligomerization upon membrane binding
PROPPINs (β-propellers that bind polyphosphoinositides) are PtdIns3P and PtdIns(3,5)P(2) binding autophagy related proteins. They contain two phosphatidylinositolphosphate (PIP) binding sites and a conserved FRRG motif is essential for PIP binding. Here we present the 2.0 Å resolution crystal struct...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5656675/ https://ncbi.nlm.nih.gov/pubmed/29070817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14337-5 |
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