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Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family

β-propellers that bind polyphosphoinositides (PROPPINs), a eukaryotic WD-40 motif-containing protein family, bind via their predicted β-propeller fold the polyphosphoinositides PtdIns3P and PtdIns(3,5)P(2) using a conserved FRRG motif. PROPPINs play a key role in macroautophagy in addition to other...

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Detalhes bibliográficos
Main Authors: Krick, Roswitha, Busse, Ricarda A., Scacioc, Andreea, Stephan, Milena, Janshoff, Andreas, Thumm, Michael, Kühnel, Karin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409749/
https://ncbi.nlm.nih.gov/pubmed/22753491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205128109
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