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Characterization of PROPPIN-Phosphoinositide Binding and Role of Loop 6CD in PROPPIN-Membrane Binding

PROPPINs (β-propellers that bind polyphosphoinositides) are a family of PtdIns3P- and PtdIns(3,5)P(2)-binding proteins that play an important role in autophagy. We analyzed PROPPIN-membrane binding through isothermal titration calorimetry (ITC), stopped-flow measurements, mutagenesis studies, and mo...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Busse, Ricarda A., Scacioc, Andreea, Krick, Roswitha, Pérez-Lara, Ángel, Thumm, Michael, Kühnel, Karin
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423041/
https://ncbi.nlm.nih.gov/pubmed/25954880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.03.045
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