It takes two to tango: PROPPINs use two phosphoinositide-binding sites

PROPPINs are a family of PtdIns3P and PtdIns(3,5)P(2)-binding proteins. The crystal structure now unravels the presence of two distinct phosphoinositide-binding sites at the circumference of the seven bladed β-propeller. Mutagenesis analysis of the binding sites shows that both are required for norm...

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Bibliographic Details
Main Authors:	Thumm, Michael, Busse, Ricarda A., Scacioc, Andreea, Stephan, Milena, Janshoff, Andreas, Kühnel, Karin, Krick, Roswitha
Format:	Artigo
Language:	Inglês
Published:	Landes Bioscience 2013
Subjects:	Autophagic Punctum
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3542210/ https://ncbi.nlm.nih.gov/pubmed/23069643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.22400
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It takes two to tango: PROPPINs use two phosphoinositide-binding sites

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