Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers

In mammalian development, epigenetic modifications, including DNA methylation patterns, play a crucial role in defining cell fate but also represent epigenetic barriers that restrict developmental potential. At two points in the life cycle, DNA methylation marks are reprogrammed on a global scale, c...

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Hlavní autoři: Seisenberger, Stefanie, Peat, Julian R., Hore, Timothy A., Santos, Fátima, Dean, Wendy, Reik, Wolf
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2013
Témata:
Part II: Molecular mechanisms working in the mammalian life cycle
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539359/
https://ncbi.nlm.nih.gov/pubmed/23166394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2011.0330
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