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Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos

Mouse embryos undergo genome-wide methylation reprogramming by demethylation in early preimplantation development, followed by remethylation thereafter. Here we show that genome-wide reprogramming is conserved in several mammalian species and ask whether it also occurs in embryos cloned with the use...

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Detalhes bibliográficos
Main Authors: Dean, Wendy, Santos, Fátima, Stojkovic, Miodrag, Zakhartchenko, Valeri, Walter, Jörn, Wolf, Eckhard, Reik, Wolf
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC61110/
https://ncbi.nlm.nih.gov/pubmed/11717434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241522698
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