Canonical Wnt signaling in megakaryocytes regulates proplatelet formation

Wnt signaling is involved in numerous aspects of vertebrate development and homeostasis, including the formation and function of blood cells. Here, we show that canonical and noncanonical Wnt signaling pathways are present and functional in megakaryocytes (MKs), with several Wnt effectors displaying...

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Hlavní autoři: Macaulay, Iain C., Thon, Jonathan N., Tijssen, Marloes R., Steele, Brian M., MacDonald, Bryan T., Meade, Gerardene, Burns, Philippa, Rendon, Augusto, Salunkhe, Vishal, Murphy, Ronan P., Bennett, Cavan, Watkins, Nicholas A., He, Xi, Fitzgerald, Desmond J., Italiano, Joseph E., Maguire, Patricia B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Platelets and Thrombopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538329/
https://ncbi.nlm.nih.gov/pubmed/23160460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-416875
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