Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein

Bone marrow megakaryocytes produce platelets by extending long cytoplasmic protrusions, designated proplatelets, into sinusoidal blood vessels. Although microtubules are known to regulate platelet production, the underlying mechanism of proplatelet elongation has yet to be resolved. Here we report t...

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Publicat a:Blood
Autors principals: Bender, Markus, Thon, Jonathan N., Ehrlicher, Allen J., Wu, Stephen, Mazutis, Linas, Deschmann, Emoke, Sola-Visner, Martha, Italiano, Joseph E., Hartwig, John H.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Platelets and Thrombopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311231/
https://ncbi.nlm.nih.gov/pubmed/25411426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-600858
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