Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein

Bone marrow megakaryocytes produce platelets by extending long cytoplasmic protrusions, designated proplatelets, into sinusoidal blood vessels. Although microtubules are known to regulate platelet production, the underlying mechanism of proplatelet elongation has yet to be resolved. Here we report t...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Bender, Markus, Thon, Jonathan N., Ehrlicher, Allen J., Wu, Stephen, Mazutis, Linas, Deschmann, Emoke, Sola-Visner, Martha, Italiano, Joseph E., Hartwig, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311231/
https://ncbi.nlm.nih.gov/pubmed/25411426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-600858
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