Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein

Bone marrow megakaryocytes produce platelets by extending long cytoplasmic protrusions, designated proplatelets, into sinusoidal blood vessels. Although microtubules are known to regulate platelet production, the underlying mechanism of proplatelet elongation has yet to be resolved. Here we report t...

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Publicado en:Blood
Autores principales: Bender, Markus, Thon, Jonathan N., Ehrlicher, Allen J., Wu, Stephen, Mazutis, Linas, Deschmann, Emoke, Sola-Visner, Martha, Italiano, Joseph E., Hartwig, John H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311231/
https://ncbi.nlm.nih.gov/pubmed/25411426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-600858
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