Proplatelet generation in the mouse requires PKCε-dependent RhoA inhibition

During thrombopoiesis, megakaroycytes undergo extensive cytoskeletal remodeling to form proplatelet extensions that eventually produce mature platelets. Proplatelet formation is a tightly orchestrated process that depends on dynamic regulation of both tubulin reorganization and Rho-associated, coile...

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Detalhes bibliográficos
Main Authors: Gobbi, Giuliana, Mirandola, Prisco, Carubbi, Cecilia, Masselli, Elena, Sykes, Stephen M., Ferraro, Francesca, Nouvenne, Antonio, Thon, Jonathan N., Italiano, Joseph E., Vitale, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952532/
https://ncbi.nlm.nih.gov/pubmed/23838351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-490599
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