Multimechanistic Tumor Targeted Oncolytic Virus Overcomes Resistance in Brain Tumors

Only a subset of cancer patients inoculated with oncolytic herpes simplex virus (oHSV) type-1 has shown objective response in phase 1 and 2 clinical trials. This has raised speculations whether resistance of tumor cells to oHSV therapy may be a limiting factor. In this study, we have identified esta...

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Autores principales: Tamura, Kaoru, Wakimoto, Hiroaki, Agarwal, Aayush S, Rabkin, Samuel D, Bhere, Deepak, Martuza, Robert L, Kuroda, Toshihiko, Kasmieh, Randa, Shah, Khalid
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538303/
https://ncbi.nlm.nih.gov/pubmed/22929661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.175
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