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microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis

BACKGROUND: MicroRNAs (miRs) are known to play a pivotal role in tumorigenesis, controlling cell proliferation and apoptosis. In this study, we investigated the potential of miR-7 to prime resistant tumor cells to apoptosis in glioblastoma (GBM). METHODS: We created constitutive and regulatable miR-...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Bhere, Deepak, Tamura, Kaoru, Wakimoto, Hiroaki, Choi, Sung Hugh, Purow, Benjamin, Debatisse, Jeremy, Shah, Khalid
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777493/
https://ncbi.nlm.nih.gov/pubmed/29016934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox138
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