Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

BACKGROUND: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. METHODS: We investigated whether acquired cisplatin resistance affects sensitivity to re...

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Detalhes bibliográficos
Main Authors: Duiker, E W, Meijer, A, van der Bilt, A R M, Meersma, G J, Kooi, N, van der Zee, A G J, de Vries, E G, de Jong, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078595/
https://ncbi.nlm.nih.gov/pubmed/21487429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.84
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