Development of a radioiodinated apoptosis–inducing ligand, rhTRAIL, and a radiolabelled agonist TRAIL receptor antibody for clinical imaging studies

BACKGROUND AND PURPOSE: The TNF-related apoptosis inducing ligand (TRAIL) induces apoptosis through activation of the death receptors, TRAIL-R1 and TRAIL-R2. Recombinant human (rh) TRAIL and the TRAIL-R1 directed monoclonal antibody mapatumumab are currently clinically evaluated as anticancer agents...

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Detalhes bibliográficos
Main Authors: Duiker, EW, Dijkers, ECF, Lambers Heerspink, H, de Jong, S, van der Zee, AGJ, Jager, PL, Kosterink, JGW, de Vries, EGE, Lub-de Hooge, MN
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413857/
https://ncbi.nlm.nih.gov/pubmed/22014269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01718.x
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