Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL

Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). The activity of the insulin-like growth factor 1 (IGF-1) survival pathway is often increased in cance...

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Publicat a:Anal Cell Pathol (Amst)
Autors principals: Pennarun, Bodvael, Kleibeuker, Jan H., Oenema, Tjitske, Stegehuis, Janet H., de Vries, Elisabeth G.E., de Jong, Steven
Format: Artigo
Idioma:Inglês
Publicat: IOS Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605769/
https://ncbi.nlm.nih.gov/pubmed/20978316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/ACP-CLO-2010-0549
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