Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5

BACKGROUND: rhTRAIL is a therapeutic agent, derived from the TRAIL cytokine, which induces apoptosis in cancer cells by activating the membrane death receptors 4 and 5 (DR4 and DR5). Here, we investigated each receptor's contribution to rhTRAIL sensitivity and rhTRAIL resistance. We assessed wh...

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Detalhes bibliográficos
Main Authors: van Geelen, Caroline MM, Pennarun, Bodvael, Le, Phuong TK, de Vries, Elisabeth GE, de Jong, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045356/
https://ncbi.nlm.nih.gov/pubmed/21272366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-39
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