Multiple Interactions Between Cancer Cells and the Tumor Microenvironment Modulate TRAIL Signaling: Implications for TRAIL Receptor Targeted Therapy

Tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL) signaling is far more complex than initially anticipated and can lead to either anti- or protumorigenic effects, hampering the successful clinical use of therapeutic TRAIL receptor agonists. Cell autonomous resistance mechanisms h...

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Detalhes bibliográficos
Main Authors: Margot de Looff, Steven de Jong, Frank A. E. Kruyt
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-07-01
Colecção:Frontiers in Immunology
Assuntos:
TRAIL
TME
cytokines
cancer
immune suppression
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.01530/full
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