DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase

Budding yeast cells suffering a single unrepaired double-strand break (DSB) trigger the Mec1 (ATR)-dependent DNA damage response that causes them to arrest before anaphase for 12–15 h. Here we find that hyperactivation of the cytoplasm-to-vacuole (CVT) autophagy pathway causes the permanent G2/M arr...

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Bibliographic Details
Main Authors: Dotiwala, Farokh, Eapen, Vinay V., Harrison, Jacob C., Arbel-Eden, Ayelet, Ranade, Vikram, Yoshida, Satoshi, Haber, James E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538254/
https://ncbi.nlm.nih.gov/pubmed/23169651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218065109
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