Molecular Basis of Allele-Specific Efficacy of a Blood-Stage Malaria Vaccine: Vaccine Development Implications

The disappointing efficacy of blood-stage malaria vaccines may be explained in part by allele-specific immune responses that are directed against polymorphic epitopes on blood-stage antigens. FMP2.1/AS02(A), a blood-stage candidate vaccine based on apical membrane antigen 1 (AMA1) from the 3D7 strai...

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Hlavní autoři: Ouattara, Amed, Takala-Harrison, Shannon, Thera, Mahamadou A., Coulibaly, Drissa, Niangaly, Amadou, Saye, Renion, Tolo, Youssouf, Dutta, Sheetij, Heppner, D. Gray, Soisson, Lorraine, Diggs, Carter L., Vekemans, Johan, Cohen, Joe, Blackwelder, William C., Dube, Tina, Laurens, Matthew B., Doumbo, Ogobara K., Plowe, Christopher V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537449/
https://ncbi.nlm.nih.gov/pubmed/23204168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis709
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