Molecular Basis of Allele-Specific Efficacy of a Blood-Stage Malaria Vaccine: Vaccine Development Implications

The disappointing efficacy of blood-stage malaria vaccines may be explained in part by allele-specific immune responses that are directed against polymorphic epitopes on blood-stage antigens. FMP2.1/AS02(A), a blood-stage candidate vaccine based on apical membrane antigen 1 (AMA1) from the 3D7 strai...

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Main Authors: Ouattara, Amed, Takala-Harrison, Shannon, Thera, Mahamadou A., Coulibaly, Drissa, Niangaly, Amadou, Saye, Renion, Tolo, Youssouf, Dutta, Sheetij, Heppner, D. Gray, Soisson, Lorraine, Diggs, Carter L., Vekemans, Johan, Cohen, Joe, Blackwelder, William C., Dube, Tina, Laurens, Matthew B., Doumbo, Ogobara K., Plowe, Christopher V.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537449/
https://ncbi.nlm.nih.gov/pubmed/23204168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis709
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