Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria: Implications for Vaccine Development

Vaccines directed against the blood stages of Plasmodium falciparum malaria are intended to prevent the parasite from invading and replicating within host cells. No blood-stage malaria vaccine has shown clinical efficacy in humans. Most malaria vaccine antigens are parasite surface proteins that hav...

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Detalhes bibliográficos
Main Authors: Takala, Shannon L., Coulibaly, Drissa, Thera, Mahamadou A., Batchelor, Adrian H., Cummings, Michael P., Escalante, Ananias A., Ouattara, Amed, Traoré, Karim, Niangaly, Amadou, Djimdé, Abdoulaye A., Doumbo, Ogobara K., Plowe, Christopher V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822345/
https://ncbi.nlm.nih.gov/pubmed/20165550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000257
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