Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria: Implications for Vaccine Development

Vaccines directed against the blood stages of Plasmodium falciparum malaria are intended to prevent the parasite from invading and replicating within host cells. No blood-stage malaria vaccine has shown clinical efficacy in humans. Most malaria vaccine antigens are parasite surface proteins that hav...

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Autori principali: Takala, Shannon L., Coulibaly, Drissa, Thera, Mahamadou A., Batchelor, Adrian H., Cummings, Michael P., Escalante, Ananias A., Ouattara, Amed, Traoré, Karim, Niangaly, Amadou, Djimdé, Abdoulaye A., Doumbo, Ogobara K., Plowe, Christopher V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822345/
https://ncbi.nlm.nih.gov/pubmed/20165550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000257
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