Epitope-based sieve analysis of Plasmodium falciparum sequences from a FMP2.1/AS02(A) vaccine trial is consistent with differential vaccine efficacy against immunologically relevant AMA1 variants.

To prevent premature dismissal of promising vaccine programs, it is critical to determine if lack of efficacy in the field is due to allele specific-efficacy, rather than to the lack of immunogenicity of the candidate antigen. Here we use samples collected during a field trial of the AMA1-based FMP2...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine
Main Authors: Ouattara, Amed, Niangaly, Amadou, Adams, Matthew, Coulibaly, Drissa, Kone, Abdoulaye K., Traore, Karim, Laurens, Matthew B., Tolo, Youssouf, Kouriba, Bourema, Diallo, Dapa A., Doumbo, Ogobara K., Plowe, Christopher V., Djimdé, Abdoulaye, Thera, Mahamadou A., Laufer, Miriam K., Takala-Harrison, Shannon, Silva, Joana C.
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375901/
https://ncbi.nlm.nih.gov/pubmed/32571720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2020.06.035
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items