Epitope-based sieve analysis of Plasmodium falciparum sequences from a FMP2.1/AS02(A) vaccine trial is consistent with differential vaccine efficacy against immunologically relevant AMA1 variants.

To prevent premature dismissal of promising vaccine programs, it is critical to determine if lack of efficacy in the field is due to allele specific-efficacy, rather than to the lack of immunogenicity of the candidate antigen. Here we use samples collected during a field trial of the AMA1-based FMP2...

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Gepubliceerd in:Vaccine
Hoofdauteurs: Ouattara, Amed, Niangaly, Amadou, Adams, Matthew, Coulibaly, Drissa, Kone, Abdoulaye K., Traore, Karim, Laurens, Matthew B., Tolo, Youssouf, Kouriba, Bourema, Diallo, Dapa A., Doumbo, Ogobara K., Plowe, Christopher V., Djimdé, Abdoulaye, Thera, Mahamadou A., Laufer, Miriam K., Takala-Harrison, Shannon, Silva, Joana C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375901/
https://ncbi.nlm.nih.gov/pubmed/32571720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2020.06.035
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