Extracellular Nef Protein Targets CD4(+) T Cells for Apoptosis by Interacting with CXCR4 Surface Receptors

The effects of soluble Nef protein on CD4(+) T cells were examined. CD4(+)-T-cell cultures exposed to soluble Nef were analyzed for apoptosis by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling and hallmarks of apoptosis including cytoplasmic shrinkage, nuclear fragmentati...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: James, Cleve O., Huang, Ming-Bo, Khan, Mafuz, Garcia-Barrio, Minerva, Powell, Michael D., Bond, Vincent C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2004
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC353732/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14990729/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.6.3099-3109.2004
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