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Secretion Modification Region-Derived Peptide Disrupts HIV-1 Nef's Interaction with Mortalin and Blocks Virus and Nef Exosome Release

Nef is secreted from infected cells in exosomes and is found in abundance in the sera of HIV-infected individuals. Secreted exosomal Nef (exNef) induces apoptosis in uninfected CD4(+) T cells and may be a key component of HIV pathogenesis. The exosomal pathway has been implicated in HIV-1 virus rele...

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書目詳細資料
Main Authors: Shelton, Martin N., Huang, Ming-Bo, Ali, Syed A., Powell, Michael D., Bond, Vincent C.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255900/
https://ncbi.nlm.nih.gov/pubmed/22013042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05720-11
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