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Secretion Modification Region-Derived Peptide Disrupts HIV-1 Nef's Interaction with Mortalin and Blocks Virus and Nef Exosome Release
Nef is secreted from infected cells in exosomes and is found in abundance in the sera of HIV-infected individuals. Secreted exosomal Nef (exNef) induces apoptosis in uninfected CD4(+) T cells and may be a key component of HIV pathogenesis. The exosomal pathway has been implicated in HIV-1 virus rele...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3255900/ https://ncbi.nlm.nih.gov/pubmed/22013042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05720-11 |
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