Characterization of Nef-CXCR4 Interactions Important for Apoptosis Induction

The HIV-1 Nef protein was analyzed for apoptotic structural motifs that interact with the CXCR4 receptor and induce apoptosis in CD4(+) lymphocytes. Two apoptotic motifs were identified. One centered on Nef amino acids (aa) 50 to 60, with the overlapping 20-mer peptides retaining about 82% of the ac...

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Vydáno v:J Virol
Hlavní autoři: Huang, Ming-Bo, Jin, Ling Ling, James, Cleve O., Khan, Mahfuz, Powell, Michael D., Bond, Vincent C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2004
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521796/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15452229/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.20.11084-11096.2004
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